Pattern of immunoglobulin production in human lymphoblastoid cell lines
نویسندگان
چکیده
منابع مشابه
Receptors for complement and immunoglobulin on human leukemic cells and human lymphoblastoid cell lines.
The bone marrow-derived (B) lymphocyte can be identified by the presence of easily detectable surface immunoglobulin and a receptor for antigen-antibody-complement complexes (EAC'). Monocytes and macrophages also bear a receptor for EAC' and in addition possess a receptor for red cell-IgG complexes (EA). Thymus-derived (T) lymphocytes bear neither of these receptors. The cells of 15 patients wi...
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The synthesis and secretion of immunoglobulin M (IgM), as well as the relative ratio of membrane and secretory mu heavy chain (mu m and mu s, respectively), were evaluated in mycoplasma-contaminated B lymphoblastoid cell lines. The ratio of mu m to mu s was drastically lowered in infected cultures, and mu s chains could now combine with light chains. A 50 to 100% increase in IgM synthesis occur...
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Human Epstein-Barr virus-immortalized lymphoblastoid B-cell lines tested positive by PCR for simian virus 40 (SV40) DNA (22 of 42 cell lines, 52.3%). B lymphocytes or tissues from which B-cell lines derived were also SV40 positive. In situ hybridization showed that SV40 DNA was present in the nucleus of a small fraction (1/250) of cells. SV40 T-antigen mRNA was detected by reverse transcription...
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Human diploid fibroblast cells produce a spectrum of necessary growth factors and extracellular matrix (ECM) components essential for growth and proliferation of a variety of other cell types. In this study, the effect of five human embryonic fibroblast cell lines, isolated from liver, lung, skin and foreskin tissues, was investigated. A coculture system analyse was employed to cloning efficien...
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Introduction: Interleukin-2 (IL-2) as a T helper type 1 (Th1) cytokine has an important role Background and Objective: Interleukin-2 (IL-2) as a T helper type 1 (Th1) cytokine has an important role in activation, growth and differentiation of several immune cells. Moreover IL-2 is known as a pro-inflammatory and anti-tumoral cytokine. In addition deysregulation of IL-2 in some diseases such as ...
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ژورنال
عنوان ژورنال: Okayama Igakkai Zasshi (Journal of Okayama Medical Association)
سال: 1977
ISSN: 0030-1558,1882-4528
DOI: 10.4044/joma1947.89.7-8_949